Home
Toolbox
Resource
Workflow
Tutorials
Citations
Downloads
Mutation Al-Predictor Flow
Gene-to-Mutation Flow
News & Insights
Genetic Encyclopedia
Frontiers
Industry Insights
Case Studies
About Us
About the Site
Contact Us
Private Policy
User Agreement
COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
Log In
|
Sign Up
中文
基因编辑小鼠
Prdx6
tm4.1Abf
Alias:
H26A Prdx6
Prdx6 H26A
H26A Prdx6 knock-in
Need animal model construction services?
Click here >>
Create a favorites folder
Cancel
Confirm
Add To Favorites
Select a favorites
Description
New favorites >>
Cancel
Confirm
Favorite
基础信息
表型特征
文献报道
这个突变等位基因包含改变了mRNA序列(NM_007453.4)第76和77位对应核苷酸的点突变,从CA变为GC,将第26位的CACHis密码子替换为GCCAlanine密码子(H26A)。这个His(H26)与S32和D140一起构成了磷脂酶A2(PLA2)的催化部位。通过靶向载体在第1和2外显子间插入的含Frt位点的诺卡因抗性基因座已被FLP重组酶删除,剩下单一的Frt位点。H26A突变蛋白失去了磷脂酶A2(PLA2)活性,但保留了磷脂酰胆碱酰基转移酶(LPCAT)活性。至于过氧化酶活性,它仍能还原短链氢过氧化物,但不能还原磷脂氢过氧化物(J:94077, J:231458)。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
5908015
C57BL/6
Targeted
Insertion, Nucleotide substitutions
--
1
--
1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部