在exon 1的上游和内含子1位置插入了LoxP位点,形成了一个可调控的等位基因,exon 1被敲除了。exon 1包含起始翻译位点,其缺失会导致无功能的突变体。同时,内含子1中插入的带有FRT序列的抗氨苄青霉素基因座通过Flp介导的重组被去除了。(来源:J:241413)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入
--
1
3
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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