将含有En转录接点、lox71位点、lacZ基因、neo cassette、loxP位点和lox2272位点的pUC17基因捕获载体插入了内皮4号染色体。插入导致内源序列在前320bp后截断,催化区域丢失。定量实时PCR确认了E11期胚胎中转录几乎不存在(来源:J:242754)。
Basic Information
(C57BL/6NCrlj x CBA/JNCrlj)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count