Clcn7^tm2.1Mjec

A nucleotide substitution was created in exon 7, giving rise to a glycine to arginine codon change for codon 213 (p.G213R). This mutation is equivalent to the p.G215R mutation in human, which is associated with autosomal dominant osteopetrosis type II (ADO2). A loxP site flanked neomycin resistance gene cassette that was inserted was subsequently deleted through cre-mediated recombination. (J:240468)