这个转基因构建表达了一种针对流感病毒A/SW/33(SW)中血凝素(HA)的T细胞受体,其中S1决定簇通过两个替换进行了改造,113位的R被替换为K,120位的E替换为T,来源于杂交瘤细胞S106-1。这个受体由TCRα8.3和β10基因编码,对原始的S1决定簇的亲和力远低于TCRValpha8.3/Vbeta10的转基因产品(Tg(Tcra/Tcrb)1Vbo)。来源:(J:133154)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6 x BALB/c
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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