Lrp5^tvrm111B

This ENU-induced insertion of a single C into a string of 9 successive cytosines in a highly conserved GC-rich region is predicted to result in the replacement of 39 C-terminal amino acids with 20 novel amino acids, disrupting the last 3 PPPSPxS motifs in the cytoplasmic domain and introducing a premature stop codon. (J:241491)