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中文
将人类基因插入到鼠靶基因的起始翻译位点上游，下游接鼠宿主基因的启动子。通过Cre介导的重组，删除了带有诺卡菌素抗性基因（含LoxP标记）的区域。这产生了一个由鼠启动子调控的人类敏感性溶血性链球菌毒素基因等位基因，使得表达该等位基因的细胞对DT诱导的细胞死亡敏感。(来源：J:240454)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
