携带这种转基因的小鼠表达的是缺乏C3S/C4S棕榈酰化的鼠CACNB2突变体,它是一个钙通道电压依赖性β2亚基(LTCC激活剂),连接了经典的 caveolin 结合域(CBD,RNVPPIFNDVYWIAF)。这种表达是在条件性控制下,通过小鼠Myh6(心肌肌动蛋白重链6)启动子和四环素响应元件(TRE或tetO)驱动的。转基因的表达在 Western blot 检测下显示出强效。(来源:J:263301)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
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Year
IF
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