设计了一种靶向载体,目标是将一个loxP序列和neo cassette插入基因在第4和5外显子之间,以及第6和7外显子之间的区域。随后通过Cre介导的重组去除neo cassette,导致第5和6外显子被loxP序列环绕。(来源:J:236234)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count