Otog^vbd

This ENU-induced mutation was isolated in the Munich genome wide ENU recessive mutagenesis program. Gene mapping identified a one base pair substitution, a T36351 to C36351 transition at the splice donor site of intron 29, leading to a frame-shift of translation inducing an addition of 16 new amino acids at the carboxyl-terminus and a premature stop codon. (J:234038)