L1L2_gt1 cassette被插入到染色体1的139,391,526位置,位于第七外显子上游(基于GRCm39构建)。这个 cassette 包含FRT引导的lacZ/诺卡因序列,后面跟着一个loxP位点。在第七外显子下游,再插入一个loxP位点,位置是139,392,331。通过小鼠中flp重组酶的表达,创建了一个"条件准备好"(含floxed标签)的等位基因,这会移除lacZ序列和诺卡因选择性载体,使得第七外显子被loxP位点环绕。(来源:J:226691)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
插入
--
1
9
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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