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中文
在exon 5的3'端插入了一个loxP位点。接着，插入了一个Frt-PGK-Neo-Frt-loxP的 cassette到exon 3的5'端。通过和携带Frt重组酶，由β-actin启动子驱动的 mice杂交，去除了neo cassette。这样，exons 3-5被一对loxP位点所环绕。随后的Cre介导的重组导致了exons 3-5的切除。 Western blot分析证实了纯合突变组织中没有蛋白质表达。(来源：J:237513)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
