在exon 5的3'端插入了一个单个的loxP位点。接着,将Frt-PGK-Neo-Frt-loxP片段插入到exon 3的5'端。通过与β-actin启动子驱动Frt重组酶的鼠杂交,移除了neo cassette,使得exons 3-5两侧各有一个loxP位点。(来源:J:237513)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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