将Cas9 mRNA和sgRNAs(5'-GAGAAGGGAAAATTTCTGG-3'和5'-AGGGCAGAGTGATGTTGTC-3')通过细胞质注射到囊胚中,产生了杂合子F1小鼠(来自F0的祖先杂交)和纯合子F2小鼠(来自F1的杂交)。变异范围从1-5个碱基的插入到1-1632个碱基的缺失。总共产生了12种不同的等位基因。(来源:J:226780)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count