靶向载体设计为在exon 1上游插入一个loxP位点,包含1.5kb的启动子序列,接着是一个由FRT引导的诺卡因抗性基因座,后面跟着第二个loxP位点,位于exon 2下游。通过Flp介导的重组,FRT引导的诺卡因抗性基因座被移除,使得exons 1和2成为可剪接的区域。(来源:J:239734)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Thy1a
Targeted
插入
--
1
21
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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