在 intron 36 处插入了 loxP 立场,然后通过同源重组将 FRT-loxP-neomycin-FRT-loxP 的片段插入了 intron 37。通过 Flp 介导的重组,FRT 包围的 neo 基因 cassette 被移除,使得 exon 37 成为可调节的。分析的这种携带 neomycin 选择标记的等位基因是 Ank3tm3Bnt。(来源:J:218905)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入
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1
2
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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