CRISPR/Cas技术针对Kit基因上游240kb区域和Nmu基因下游81kb处,设计了一个1.07Mb的删除区域,其中包括多个基因。左边的CRISPR靶点位于染色体5:75,408,459-75,408,481,右边的靶点位于5:76,444,361-76,444,383(基于GRCm38构建)。(来源:J:233978)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
Intergenic deletion, Intragenic deletion
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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