Cre-mediated excision of the parental Ankle1tm1(KOMP)Wtsi allele resulted in the removal of the neomycin selection cassette and critical exons (exons 2 to 9) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:235782)