Trex1^tm1.1Nyan

Exon 2 was floxed. A human cDNA containing the V235fs mutation was knocked in. This mutation creates a dominant frameshift mutation that truncates the C terminus and is associated with retinal vasculopathy with cerebral leukodystrophy. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:233654)