在exon 2上游插入了loxP位点。下游的exon 7之后插入了一个带有3' loxP的FRT引导的诺卡因抗性元件,还有一个选择性元件。通过Cre介导的重组,这些序列和2到7号外显子都被去除了。 Western blot结果显示心肌中没有蛋白表达(来源:J:238260)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
5
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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