将一种融合了2个突变型小鼠雌激素受体配体结合域(Mer; Esr1*)的 Cassette Encoding Cre,以及FRT序列标记的neo选择子插入Kit基因座,通过同源重组在ES细胞中破坏了内源性ATG。随后,通过Flp介导的重组移除了neo选择子,留下一个单独的FRT位点。(来源:J:227907)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入
--
1
27
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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