这些靶向载体是通过PR23-98J4 BAC克隆构建的。它们包含了两个小鼠 ornithine decarboxylase 的PEST序列,这些被连接到了EGFP(degEGFP)的N端,并插入了Dkk1基因的首编码区,周围带有loxP-标记的PGK-Neo cassette。Cre介导的重组会剔除PGK-Neo cassette,留下一个loxP位点。(来源:J:222398)
Basic Information
(C57BL/6NCrlj x CBA/JNCrlj)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count