这些靶向载体是通过PR23-98J4 BAC克隆构建的。它们包含了两个小鼠 ornithine decarboxylase 的PEST序列,这些被连接到了EGFP(degEGFP)的N端,并插入了Dkk1基因的首编码区,周围带有loxP-标记的PGK-Neo cassette。Cre介导的重组会剔除PGK-Neo cassette,留下一个loxP位点。(来源:J:222398)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6NCrlj x CBA/JNCrlj)F1
Targeted
插入
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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