使用了含有IRES/lacZ序列和敲除neo cassette的靶向载体,目标几乎去除了exon 3。通过Cre介导的重组,去除了含floxed neo cassette的部分。lacZ的表达尚未检测。对多个组织的定量RT-PCR研究并未在纯合突变小鼠中检测到mRNA(来源:J:237107)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
插入,基因内删除
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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