携带E57K变异的人类α-synuclein,由神经元小鼠Thy1启动子控制,已经产生了三条转基因品系。其中9号和16号为高表达线,而54号则为低表达线。通过凝胶过滤色谱,我们确认了α-synuclein的聚集体形成。(来源:J:236596)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x DBA/2)F1
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1
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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