这个等位基因是在胚胎干细胞(ES)细胞中通过同源重组产生的。小鼠的Mafa编码区域被替换为一个包含Cre重组酶开放阅读框,后面跟着FRT标记的诺卡因抗性 cassette 的 cassette。随后,通过与FLPe敲除杂交的F1小鼠去除诺卡因 cassette(来源:J:253253)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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