插入的PGK_EM7_PuDtk_bGHpA片段导致了15号染色体(Genome Build 37)上一个79碱基对的缺失,起始位置在102,801,587,结束于102,801,666。这个缺失区域包含了该微小RNA的DNA序列。该片段由一个loxP位点、一个F3位点、一个PGK-puromycin-delta-tk cassette、另一个loxP位点,以及最终的FRT位点组成。通过Cre介导的重组,选择性片段被移除了。(来源:J:226712)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
插入,基因内删除
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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