通过Cre介导的父本Aldh3a2tm1a(EUCOMM)Wtsi等位基因的去除,删除了关键的exon 4,留下插入的lacZ报告序列和诺卡因选择标记。更多关于这种IKMC等位基因以及其他靶向策略的信息,可访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml。RT-PCR和免疫印迹实验确认了RNA和蛋白质的缺失(来源:J:234695)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
插入,基因内删除
--
1
2
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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