在经过修改的第17号外显子5'端插入了一个loxP位点,该外显子带有血小板凝集素(HA)标记器,后面跟着一个由FRT引导的诺卡因抗性基因座和另一个loxP位点。通过Flp酶介导的重组移除了选择性基因座,随后通过Cre介导的重组去除了修改的第17号外显子。(来源:J:224592)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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