使用含有FRT位点周边NEO筛选元件的靶向载体,插入了位于目标基因exon 2外侧的loxP位点。这个筛选元件被置于exon 2之后,又在exon 2上游插入了另一个loxP位点。通过Flp介导的重组,去除了这个筛选元件。(来源:J:232709)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
3
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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