这个位点通过包含普遍存在的CAG启动子、可删除的终止子和人类cDNA的构建进行靶向。构建中还包括了目标位点的人类同源基因的启动子和外显子,从而恢复了该位点的功能。终止子通过Cre介导的重组被去除,允许插入的人类cDNA转录。(来源:J:233357)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
2
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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