Tg(Myh6-Pln*R9C)#Ces

The mouse promoter drives heart-specific expression of the mouse cDNA with nucleotide substitution(s) that result(s) in the amino acid substitution of cystein for arginine at position 9 (R9C). Two unnamed lines were generated. The pound symbol is used when no line is specified and/or lines are pooled. In one of the lines, the insertion site contains a transgenic array of 13 expression cassettes, arranged in a head-to-tail tandem orientation. The insertion site is located in the bidirectional promoter of the Myh6 gene and the gene for the regulatory noncoding RNA Mhrt. Expression Mhrt from this allele in transgenic mice exhibits profound deregulation. (J:82353, J:339014)