在exon 3前面插入了floxed的诺卡因抗性 cassette,然后在exon 6后面增加了一个loxP位点。这些小鼠与Ella-Cre Deleter小鼠杂交,目的是去除诺卡因抗性 cassette以及exons 3到6,留下exon 2和7之间仅有一个loxP位点。 Western blot分析证实了成年纯合突变小鼠大脑匀浆中无蛋白表达。(来源:J:228428)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6NTac x 129S6/SvEvTac)F1
Targeted
插入,基因内删除
--
1
--
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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