这个转基因构建包含了人类MAPT基因的cDNA,编码1N4R亚型,带有上游的内含子序列(来自pCI-neo载体),一个Kozak序列,以及下游的牛生长激素的polyadenylation序列,所有这些都受到tetO,即四环素响应性调节元件(TRE-tight)的控制。来源:(J:233816)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
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插入
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1
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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