将tTA的开放阅读框插入人类PMP22基因的第二个外显子,YAC 49G7上,这样PMP22基因的起始翻译被用作tTA ORF的起始。YAC上的PMP22基因被打断,无法表达。tTA在施万细胞中表达。(来源:J:69545)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x CBA/Ca)F1
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插入
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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