外显子9被替换成一个floxed剪接接受器/新霉素抗性基因座,以及一个经过修改的外显子9,其中G到A的变异导致第545位氨基酸由赖氨酸替换为谷氨酸(位点E545K)。通过Cre介导的重组,选择性基因座被去除了。(来源:J:222915)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
Insertion, Single point
--
1
43
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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