将带有5'端病毒2A多肽(如T2A)的哺乳动物优化的噬菌体D6特异性重组酶基因(dreo)替换掉2号外显子的终止密码子和3'端41bp的UTR,但不改变编码序列。通过phiC31介导的重组,移除了重组酶基因下游插入的诺卡因抗性元件。(来源:J:232241)
Basic Information
(129S6/SvEvTac x C57BL/6NCrl)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count