编码序列被替换成一个带有floxed Neo抗性标记的 cassette,以及一个经过修改的编码序列,其中的C到T替换导致第159位的Valine被Alanine替换(A159V)。这种突变在人类癌症中已被观察到。随后,通过Cre介导的重组去除了选择性标记 cassette。(来源:J:222783)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
Insertion, Single point
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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