Kat6a^{tm1c(EUCOMM)Wtsi}

The L1L2_gt0 cassette was inserted at position 23392698 of Chromosome 8 upstream of the critical exon 4 (the second coding exon) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 4 (the second coding exon) at position 23393492. The critical exon 4 (the second coding exon) is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:224155)