Cre-mediated excision of the parental Ptchd1tm1a(KOMP)IcsOrl allele resulted in the removal of the promoter-driven neomycin selection cassette and exon 2 leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)