Log In|Sign Up
中文
这个转基因编码了一种融合的朊蛋白，其中鼠源蛋白的N端八聚体重复区域被鸡源蛋白的类似区域替换，后者含有九个串联的六肽序列PHNPGY。纯合的转基因小鼠和内源Prnp基因敲除个体在正常水平上表达这种融合蛋白，且有正确的膜定位和构象。这种替换影响了蛋白质的金属配位特性。(来源：J:169366)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
