大部分exon 1编码区域和exon 1至内含子1的接合位点被一个内切框的EGFP-bGH-pA-FRT-neo-FRT cassette通过同源重组替换。通过Flp介导的重组,去除了含FRT标签的neo cassette。尽管预测为功能丧失的等位基因,但无论是杂合子还是纯合子小鼠都没有明显的表型异常。(来源:J:229960)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Thy1a
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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