大部分exon 1编码区域和exon 1至内含子1的接合位点被一个内切框的EGFP-bGH-pA-FRT-neo-FRT cassette通过同源重组替换。通过Flp介导的重组,去除了含FRT标签的neo cassette。尽管预测为功能丧失的等位基因,但无论是杂合子还是纯合子小鼠都没有明显的表型异常。(来源:J:229960)
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cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count