Scn1a^em6(IMPC)Tcp

This allele, from project TCPR0246, was generated at The Centre for Phenogenomics by injecting Cas9 mRNA and one guide RNA with spacer sequence AGTCGTTCATGTGCCAACGT. This resulted in a 1 bp insertion at Chr2:66319540 in OTTMUSE00000158516. This mutation is predicted to cause a frameshift with amino acid changes after residue 932 and early truncation 63 amino acids later (p.W932Lfs*65). (GRCm38). (J:165963)