这个来自TCPR0410项目的等位基因是在phenogenomics中心通过向细胞注射Cas9 mRNA和四条带有TCAATACCTTGGTCTTTCCA和TTTGCAATTATCGGAAGTGT特定 Spacer序列的guide RNA,目标是ENSMUSE00000617176和ENSMUSE00000617175基因的5'端以及ATCCCGCAGTCTGGAGTCTT和ACCACAGTAAACTGAGCTGT的3'端,实现了对 Chr14:50791871 至 50794011(GRCm38染色体)的2,142bp缺失。 (引用:J:165963)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NCrl
Endonuclease-mediated
基因内删除
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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