这个等位基因来自TCPR0409项目,由中心性表观基因组学通过向细胞注射Cas9 mRNA和四种带有spacer序列的guide RNA(GGGGAGGTCCTCCGTCATCC、TCAGCACTTCAGGCCAGGTC、GTGAGTTGGGATATTCTTGC和GGCCTGCTGCTCTCCCCGTG)生成。这导致了染色体13的三个变异:8569440位置的缺失-T插入CCTCCTCTGA,一个1140bp的染色体13从8569541到8570680的删除;以及85670687位置的插入-T(GRCm38建库版本)。(来源:J:165963)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NCrl
Endonuclease-mediated
基因内删除
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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