设计了一个靶向载体,包含在第7外显子两侧的loxP位点。载体插入了内含子6的FRT引导的诺卡因(neo)抗性元件和内含子7的FRT引导的puromycin( puromycin)抗性元件。通过Flp介导的重组,FRT引导的neo和puro元件被去除,使得第7外显子成为可调节的。(来源:J:227671)
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cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count