Tg(CD68-Prkaa1*T172D)1Dbrh

The transgene was designed to have the human CD68-IVS-1 promoter (~1 kbp of human CD68 5' flanking sequence with the 83 bp first intron enhancer [IVS-1])direct expression of an AMP-activated protein kinase catalytic alpha 1 cDNA sequence harboring the constitutively active threonine 172 to aspartic acid amino acid substitution (T172D) with amino-terminal myc epitope tag, all followed by a polyadenylation signal. The investigator does not indicate organism source of the expressed gene (e.g. human, mouse, etc.). (J:101977)