在loxP位点附近,替换了162个腺苷酸-尿苷酸丰富元件(ARE)序列的诺卡因抗性基因座。通过Cre介导的重组移除了neo cassette。ARE序列的缺失会延长mRNA的半衰期,并在正常生理条件下导致IFN-gamma的低水平持续表达。(来源:J:220784)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
7
15

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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