一个反向排列的新cassette替换了包含7个外显子,包括起始ATG位点的基因组区域。 Western blot分析证实了纯合小鼠骨骼肌中没有表达(来源:J:220810)
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A neo cassette in inverse orientation replaced a genomic region containing 7 exons including the ATG start site. Western blot analysis confirmed the absence of expression in skeletal muscle from homozygous mice. (J:220810)