一段经过密码子优化的第3外显子版本,包含33个同义突变,将27个稀有密码子替换为更常见的,同时用一个可删除的neo cassette替换了原有的内源性第3外显子。通过Cre介导的重组,移除了neo cassette。(来源:J:220039)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
Insertion, Nucleotide substitutions
--
1
37
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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