Trp53^tm2.1Umol

Exons 4 through 9 were replaced with the corresponding human sequence with a mutation in exon 7 that results in the amino acid substitution of glycine with serine at position 245 (p.G245S). Flp-mediated recombination removed the FRT site flanked neomycin resistance cassette inserted into intron 10. (J:228632)